实验结果完全符合预期。在野生型HEK293T细胞中，“附加编辑”几乎无法诱导任何碱基突变。然而，一旦敲除了TARG1基因，情况发生逆转：在目标胸腺嘧啶位点，碱基突变频率显著提升。例如，在EMX1基因靶点，突变频率从几乎为零跃升至约9%。这一结果证实TARG1是阻碍“附加编辑”在人类细胞中发挥作用的主要障碍。

Organisms like eukaryotes and prokaryotes have sophisticated mechanisms of DNA repair after damage. Failure of repairing the DNA damage is considered to be the cause of induction of cell death, ...

The giant DNA loops were discovered through a careful study of saliva samples from 56 volunteers, with further tests ...

Maria Jasin, PhD, whose research on DNA repair has transformed our understanding of cancers, has been selected as the 2025 recipient of the Greengard Prize.

Researchers at the University of Bath have discovered how DNA damage caused by a faulty DNA protection and repair system can ...

Researchers from the University of Birmingham have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question. The publication of two papers ...

Researchers have unveiled a new type of nanostructure that dramatically improves CRISPR delivery. Called lipid nanoparticle ...

A new study uncovers how working at 35,000 feet may disrupt DNA repair and immune function in flight attendants, offering fresh insights into the health risks faced by cabin crews and the urgent need ...

Reporting in Nature, scientists have identified a novel process that protects the ends of chromosomes from incorrectly applied DNA repair.. | Cell And Molecular Biology ...

An artistic rendering of the concept of DNA damage and repair. Numerous diseases are linked to or caused by alterations that affect genomic integrity and the ability of cells to function and divide ...

Hz: a frequency believed to promote dna repair and positive transformation. Let the soothing tones guide you through a ...