[GET ANSWER] how are the non crossover products of double strand break repair dsbr and synthesis dependent strand annealing sdsa different dsbr sdsa answer bank non crossover product does not contain dna 07268

PolyADP-ribose polymerase (PARP) plays a key role in the repair of DNA single-strand breaks. In the presence of the PARP inhibitor olaparib, single-strand breaks accumulate. When a replication fork encounters a single-strand break, it converts it to a double-strand break, which in normal cells is then repaired by homologous recombination. In cells defective for homologous recombination, however, inhibition of PARP triggers cell death. Patients who have only one functional copy of the Brcal gene,

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

4.1.1: Homologous recombination

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